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Adrenal Health6 min read

Best Cortisol Supplements: What Works, What Doesn't

Best Cortisol Supplements: Good, Bad, and Ugly What Are Cortisol Supplements and How Do They Work? Cortisol, a steroid hormone generated by the adrenal glands, is critical in regulating metabolism, inflammation, and the body’s pressure response. It also helps regulate blood sugar, blood pressure, and immune function. But excess or insufficient cortisol can be dangerously destabilizing, leading to fatigue, […]

Dr. Ava Bell-Taylor, M.D.

Board-Certified OB/GYN & Functional Medicine Physician

January 29, 2025
Best Cortisol Supplements: What Works, What Doesn't

If you're struggling with best cortisol supplements, you're not alone — millions of women experience this, and understanding the root cause is the first step toward real relief.

Best Cortisol Supplements: Good, Bad, and Ugly

cortisol-supplements

What Are Cortisol Supplements and How Do They Work?

Cortisol, a steroid hormone generated by the adrenal glands, is critical in regulating metabolism, inflammation, and the body’s pressure response. It also helps regulate blood sugar, blood pressure, and immune function. But excess or insufficient cortisol can be dangerously destabilizing, leading to fatigue, weight gain, anxiety, and mood swings.

To address these conditions, many people try cortisol supplements, which come in two broad categories:

  • Cortisol Blockers: Key for regulating elevated levels of cortisol.
  • Adrenal Support Supplements: These products coordinate with adrenal glands to help maintain energy levels.

People use these supplements to reduce stress, get better sleep, promote adrenal health, and manage their weight—including abdominal fat that’s linked to cortisol levels.

Common Cortisol Supplements

  1. Cortisol Blockers

They work by lowering excess cortisol levels brought on by stress that result in weight gain and impaired immunity, thus promoting better overall health.

Here are some of the best ingredients:

  • Phosphatidylserine: A phospholipid that reduces cortisol and enhances cognition
  • Ashwagandha: An adaptogenic herb that has been noted to reduce cortisol and alleviate stress.
  • Rhodiola Rosea: An adaptogen that promotes stress resilience and alleviates fatigue.
  • Magnesium: A chill mineral that mitigates cortisol.

2. Supplements that Support Adrenal Function

For those with adrenal fatigue or low cortisol, some of these supplements can help to restore balance and regain energy. Key ingredients include:

  • Vitamin C: For adrenal glands, how well you handle stress
  • B Vitamins (B5 & B6) – Support adrenal function & energy production.
  • Licorice Root: Helps maintain cortisol levels, especially in adrenal insufficiency.
  • Adrenal glandular extracts: Fuel critical nutrients required for adrenal health

3. Adrenal Support and Natural Cortisol Supplements

Natural Cortisol Supplements and Adrenal Support

  • These supplements may assist with normalizing cortisol levels, a natural solution:
  • Holy Basil: An herbal adaptogen with stress-reducing effects that promote adrenal health.
  • Omega-3 Fatty Acids- Helps to decrease inflammation and balance cortisol.
  • L-Theanine is a calming amino acid in green tea that helps you relax and focus.
  • It calms a body down and creates a sensation of relief from stress.
  • Valerian root: Commonly used for sleep support and natural cortisol regulation.

Benefits of Cortisol Supplements

benefits-of-corstiol-supplements

1. Stress and Anxiety Reduction

High cortisol levels can also be a contributing factor to chronic stress and anxiety. Supplements such as ashwagandha and phosphatidylserine have proven effective in lowering cortisol and supporting a feeling of calm.

2. Improved Sleep Quality

High levels of cortisol at night, for instance, can cause insomnia. Magnesium and valerian root are natural cortisol regulators that may help improve sleep patterns.

3. Weight Management

Abdominal fat storage is associated with cortisol. Cortisol blockers help you lose weight by stopping you from gaining excess fat, particularly in the abdomen area.

4. Enhanced Adrenal Function

Vitamins and adaptogenic herbs that can support the adrenal glands may increase energy and vitality in those suffering from adrenal fatigue.

5. Balanced Blood Sugar Levels

Cortisol affects glucose metabolism. Cortisol-regulating supplements can help maintain stable 

blood sugar levels and quell cravings.

Guidance on Taking Cortisol Supplements A Quick Quiz

The Fundamentals of Cortisol Supplements A Short Quiz

Here are questions to help you work through before adding cortisol supplements to your life:

1. Do you feel stressed or anxious all the time?

— If stress has wholly taken your life over, try supplements such as ashwagandha, phosphatidylserine, and Rhodiola Rosea, which may lower the stress hormone cortisol and boost mood.

2. Are you struggling with insomnia?

– Excess cortisol in the evening makes sleep impossible.” 3. Magnesium, valerian root, and L-theanine help calm you down and help you sleep better.

3. Are you fighting a bulge that you have never had before?

– High cortisol promotes stubborn belly fat. Phosphatidylserine and omega-3s These supplements may support weight management.

4. Are you always tired and fatigued?

Add adrenal support herbs like licorice root and some B vitamins to help re-establish energy and adrenal hormone production.

5. Have you ever experienced blood sugar crashes or intense cravings?

– Cortisol influences glucose metabolism, so moderating it normalizes blood sugar and cravings.

Top Cortisol Supplements of 2025

Best-cortisol-supplements-2025

 

  1. Best Overall: Ashwagandha Extract — The clinically proven ability to reduce the stress hormone cortisol by up to 30% also makes it one of the best stress relief, sleep, and relaxation options.
  2. Best weight loss & stress: Phosphatidylserine — Inhibits surplus cortisol belly fat
  3. Best Overall Support for Adrenal Fatigue: Licorice Root Extract — Supports balanced cortisol levels.
  4. Best Natural Option: Holy Basil – A natural way to regulate your cortisol and help relax you.
  5. Best Budget Pick: Magnesium Glycinate — Cheap and practical, a top option for stress 

reduction, relaxation, and sleep quality.

Are Cortisol Supplements Safe? Risks & Side Effects

Cortisol can be safely administered in supplementation, although dosage and individual can affect side effects. Here are a few possible warning signs:

  • Digestive issues: Nausea, bloating, or mild stomach discomfort may occur in some people.
  • Drowsiness: Natural cortisol reducers such as valerian root and l-theanine may cause drowsiness in their users.
  • Hormonal imbalances: Overuse of cortisol blockers can lead to fatigue, dizziness, and weakness.
  • Some supplements may interact with medications such as antidepressants, drugs for high blood pressure, or hormone therapies, possibly changing how well those treatments work.

How to Select the Best Cortisol Supplement

how-to-choose-the-right-cortisol-supplement

 

  1. Assess Your End Goals: If you’re saying bedtime herbal tea is mainly to ease your mind, rest better, bolster adrenal health, or control your weight AND choose the herbal ingredients accordingly

2.Look at the Ingredients: Avoid artificial fillers or unnecessary additives, and instead choose high-quality, clinically studied ingredients.

  1. Take Time to Read Customer Reviews: Hearing from users about their experience with a supplement can give you insight into whether it was effective and listen for any possible side effects.
  2. Use with Caution: If you have health conditions or are on medication, make sure to discuss with a doctor before starting any new supplement

5 Healthy Ways of Balancing Cortisol Without Supplements

Along with supplements, lifestyle adjustments can help you keep cortisol in a healthy range:

Quality Sleep: 7- 9 hours a night is essential for restoring natural cortisol activity.

Reduce Caffeine: Caffeine boosts cortisol levels, so avoid caffeinated teas or beverages.

Move Smart: Movement promotes cortisol balance, but be careful with too many high-intensity workouts; that can backfire.

De-Stress: Cortisol levels can be kept low with meditation, deep breathing , or yoga.

Maintain Whole food, healthy fats, and lean proteins-focused diet: Full foods, healthy fats, and lean proteins invigorate adrenal health and stress management.

Conclusion: Should You Take Cortisol Supplements?

Cortisol supplements can help with stress management, sleep enhancement, and general health enhancement. However, they should be combined with a healthy diet and lifestyle changes as part of a whole-person approach. If you think you keep cortisol in balance, speak with your healthcare provider about whether the drug is the proper method for you. Are you excited to discover the best cortisol supplement for your personal requirements? Check out our best picks and begin your improved path toward stress management today!

Dr. Ava Bell-Taylor, M.D.

Board-Certified OB/GYN & Functional Medicine Physician

Dr. Ava Bell-Taylor is a board-certified OB/GYN and functional medicine physician specializing in hormone balance, adrenal health, and whole-body wellness. She is the co-founder of Taylor MD Formulations and Taylor Medical Group in Atlanta, Georgia.

Learn more about Dr. Bell-Taylor